Comprehensive spatial map provides insights into pancreatic cancer metastases
Pancreatic cancer is notoriously difficult to treat, resulting in a five-year survival rate of roughly 12%. Approximately half of patients develop metastases shortly after diagnosis, but the biological mechanisms driving spread to specific organs are not fully understood. To provide insights, Linghua Wang, M.D., Ph.D., Anirban Maitra, M.B.B.S., and colleagues generated a comprehensive spatial atlas using 55 samples of primary tumors and...
Triplet regimen is well tolerated by patients with AML but does not improve survival outcomes
Patients with acute myeloid leukemia (AML)Â who have high-risk genetic changes and those with relapsed disease have poor outcomes with...
Gut microbiome impacts CAR T cell therapy responses, side effects in multiple myeloma
The gut microbiome has been linked to chimeric antigen receptor (CAR) T cell therapy response and related toxicities, but few researchers...
Pilot nursing study explores physical activity during and after hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is a vital treatment for blood cancers, but it is also an intense therapy with lengthy hospital stays that can reduce physical activity and muscle strength. In a pilot study led by Gisele Tlusty, Ph.D., R.N., researchers explored changes in physical activity during and after HSCT and examined the role of nurses in supporting patients. Using accelerometers, researchers tracked physical activity...
CLL-derived exosomes alter body’s immune and hematopoietic systems in CLL patients
Immunosuppression, neutropenia and anemia can occur in patients with chronic lymphocytic leukemia (CLL) – a type of blood cancer that disrupts...
Agents that cause ‘copper overload’ can overcome radiotherapy resistance in preclinical models
Radiation therapy, or radiotherapy, can successfully treat multiple cancers, but some patients develop resistance to this treatment, known...
Novel blood-based biomarker identified in newly diagnosed acute myeloid leukemia
Inflammation in patients with acute myeloid leukemia (AML) can impact responses to certain treatments, underscoring a need for better methods...